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US 9,175,055 B2Granted
Use of fibromodulin and lumican for increasing muscle mass
AssigneeAssociation Francaise Contre Les Myopathies
InventorsAntoine Kichler, Daniel Scherman
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Abstract
The invention relates to the use of fibromodulin and lumican, particularly active fragments thereof, to increase muscle mass, especially in the treatment of muscular dystrophies.
Claims14
A method for increasing muscle mass, comprising:
- administering to a subject in need thereof a composition comprising a peptide of less than 100 residues that
- comprises a sequence containing the cysteine-rich consensus region CX3CXCX9C and having at least 50% identity with SEQ ID NO:
- 1;
- and
- is capable of binding myostatin in the presence of zinc;
- so that the muscle mass of the subject is increased.
3 more elements
Dependencies are inferred from the claim text.