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US 9,175,048 B2Granted
Use of peptides as transporters intended for the internalization of molecules of interest into target cells
AssigneeUniversite Joseph Fourier
InventorsJean-Luc Erwan Claude Francis Lenormand, Romy Rothe-Walther
Life of this patent
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Abstract
The method pertains to a peptide including the amino acid sequence SEQ ID NO: 1, or a peptide including an amino acid sequence having 93%, in particular 95%, particularly 98% sequence identity homology with the sequence SEQ ID NO: 1, in order to obtain a transporter intended for the internalization of a molecule of diagnostic or therapeutic interest into the target cells.
Claims12
A composition, comprising:
- a target polypeptide selected from the group consisting of a mouse eukaryotic initiation factor 3 (eIF3-f) comprising SEQ ID NO:
- 19, human eIF3-f comprising SEQ ID NO:
- 20, and a protein having a 4.1 ezrin, radixin, moesin (FERM) domain comprising SEQ ID NO:
- 27;
- and
- a transporter polypeptide comprising the DNA-binding domain (DB) and the leucine zipper type dimerization domain (DIM) of an EBV ZEBRA protein comprising the amino acid sequence of SEQ ID NO:
- 1,
- wherein the target polypeptide is linked to the transporter polypeptide by a covalent bond, a non-covalent bond, an ionic bond, a hydrogen bond, or a hydrophobic bond.
5 more elements
A fusion protein, comprising
- a target polypeptide selected from the group consisting of mammalian eukaryotic initiation factor of 3 (eIF3-f) comprising SEQ ID NO:
- 19, human eIF3-f comprising SEQ ID NO:
- 20, and a protein having a 4.1 ezrin, radixin, moesin (FERM) domain comprising SEQ ID NO:
- 27;
- fused with a transporter polypeptide comprising the DNA-binding domain (DB) and the leucine zipper type dimerization domain (DIM) of an EBV ZEBRA protein comprising the amino acid SEQ ID NO:
- 1.
3 more elements
Dependencies are inferred from the claim text.