Methods and compositions for tumor vaccination and therapy
AssigneeThe Rockefeller University
InventorRobert B. Darnell
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Abstract
The present invention relates to peptide vaccines, pharmaceutical compositions thereof, and associated methodologies that promote the immune-mediated regression of tumors expressing an onconeural antigen, e.g. a cdr-2 antigen, HuD antigen. The cancer peptide vaccines of the present invention are antigenic peptides capable of being faithfully presented on the MHC I complex of a target cell or antigen presenting cell. This external cellular presentation of these peptides promotes a specific cytotoxic T lymphocyte (CTL)-mediated immune response against tumor cells expressing these proteins, thereby, inducing immunological reactivity.
Claims9
A composition comprising (i) an isolated polypeptide comprising the amino acid sequence of SEQ ID NO:39 and (ii) a HuD peptide, wherein the HuD peptide consists of a sequence selected from the group consisting of SEQ ID NOs:
- 146 and 147.
Dependencies are inferred from the claim text.