Antimicrobial water treatment membranes and production thereof
AssigneesBen-Gurion Unversity of the Negev Research and Development Authority, Bar-Ilan University
InventorsRoni Kasher, Ze'ev Ronen, Ehud Banin
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Abstract
The present invention discloses antimicrobial water treatment membranes, comprising a water treatment membrane, covalently attached to one or more antimicrobial peptides or derivatives thereof, either directly or via one or more tether molecules. There are also provided a process for preparing these antimicrobial membranes, and uses thereof in water treatment applications.
Claims17
An antimicrobial water treatment membrane comprising a water treatment membrane, covalently attached to one or more antimicrobial peptides or derivatives of said one or more antimicrobial peptides via one or more tether molecules, wherein said tether:
- a) is an oligomer or a polymer having a molecular weight of at least 300 grams/mol,
- b) has an extended length, in an aqueous environment, of at least 1.5 nanometers;
- and
- c) has a ratio between said molecular weight and said extended length which is lower than 1,200 g/mol per 1 nanometer;
- and further wherein said antimicrobial peptide:
- d) has an IC50 value of up to 200 μg/ml and higher than 0, against at least one biofilm-forming microorganism, and
- e) is stable against proteolysis for at least 1 week.
A process for preparing an antimicrobial water treatment membrane, said process comprising covalently attaching one or more antimicrobial peptides or derivatives of said one or more antimicrobial peptides to a water treatment membrane, via a tether molecule, wherein said tether;
- a) is an oligomer or a polymer having a molecular weight of at least 300 grams/mol,
- b) has an extended length, in an aqueous environment, of at least 1.5 nanometers;
- and
- c) has a ratio between said molecular weight and said extended length which is lower than 1,200 g/mol per 1 nanometers;
- and further wherein said antimicrobial peptide;
- d) has an IC50 value of up to 200 μg/ml and higher than 0, against at least one biofilm-forming microorganism, and
- e) is stable against proteolysis for at least 1 week.
An antimicrobial water purification process, comprising contacting a water source selected from the group consisting of sea-water, waste water, brackish water, industrial water, irrigation water, drinking water and combinations thereof, with an antimicrobial water treatment membrane comprising a water treatment membrane, covalently attached to one or more antimicrobial peptides or derivatives of said one or more antimicrobial peptides via one or more tether molecules, wherein said tether:
- a) is an oligomer or a polymer having a molecular weight of at least 300 grams/mol,
- b) has an extended length, in an aqueous environment, of at least 1.5 nanometers;
- and
- c) has a ratio between said molecular weight and said extended length which is lower than 1,200 g/mol per 1 nanometer;
- and further wherein said antimicrobial peptide:
- d) has an IC50 value of up to 200 μg/ml and higher than 0, against at least one biofilm-forming microorganism, and
- e) is stable against proteolysis for at least 1 week.
Dependencies are inferred from the claim text.