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US 9,175,030 B2Granted
Derivatives of avicin D and methods of making and using thereof
AssigneesJordan Gutterman, Valsala Haridas
InventorsPeter C. Michels, Yuri L. Khmelnitsky, Jordan Gutterman, Valsala Haridas, Vadim M. Mozhaev
Life of this patent
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Abstract
Disclosed herein are novel oxetane derivatives of avicin D, including compounds of the formula (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising these derivative compounds. Methods and intermediates useful for making the derivatives, and methods of using the derivatives and compositions thereof, including for the treatment of cancer, are also provided.
Claims8
A compound of the formula:
- wherein:
- n is 0-3, and
- R is —H or —OH;
- or a pharmaceutically acceptable salt, acetal, ketal or tautomer thereof.
1 more element
Dependencies are inferred from the claim text.