Platinum compound having amino or alkylamino-containing succinic acid derivatives as leaving group, preparation method thereof, and use thereof

A platinum compound as expressed in formula A and its pharmaceutically acceptable salt, solvate, isomer, or precursor thereof;

• wherein:
• R1 and R2 are the same or different, selected from hydrogen, alkyl, naphthenic base, alkoxy alkyl, alkylamino alkyl, heterocycle, alkenyl, and alkynyl respectively;
• wherein above alkyl, naphthenic base, alkoxy alkyl, alkyl amino alkyl, heterocycle, alkenyl, and alkynyl are unsubstituted or optionally substituted;
• R1 and R2 may form saturated or unsaturated carboncycle or heterocycle with the atom connected, which may be unsubstituted or optionally substituted;
• provided that the ring that formed by R1, R2 or R1 and R2 contains unsaturated bond, the atom of the unsaturated bond cannot be directly connected with nitrogen atom;
• R3 is selected from alkyl, naphthenic base and —R31—O—R32—;
• wherein R31 and R32 are independently selected from bond or alkyl;
• R31 is connected with nitrogen atom;
• wherein above alkyl or naphthenic base is unsubstituted or optionally substituted;
• R4 and R5 are the same or different, selected from:
• hydrogen, hydroxyl, alkyl, naphthenic base, alkoxy, alkoxy alkyl, alkylamino alkyl, heterocycle, alkenyl, or alkynyl respectively;
• wherein above alkyl, alkenyl, alkynyl, naphthenic base, alkoxy alkyl, alkylamino alkyl and heterocycle may be unsubstituted or optionally substituted;
• R4, R5 and the atoms they connected maybe together form a closed ring, which may be four-membered, five-membered, six-membered, seven-membered or eight-membered ring;
• the above ring is optionally condensed with other rings and optionally substituted.