Boronate ester compounds and pharmaceutical compositions thereof
OwnerEric L. Elliott, Abu J. Ferdous +10inventors
InventorsEric L. Elliott, Abu J. Ferdous, Michael J. Kaufman, Sonja A. Komar, Debra L. Mazaik, Quentin J. McCubbin, Phuong M. Nguyen, Vaithianathan Palaniappan, Raymond D. Skwierczynski, Nobel T. Truong, Csanad M. Varga, Peter N. Zawaneh
Life of this patent
Estimating the term…
Abstract
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
Claims13
A method for treating cancer, the method comprises administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula (II):
- or a pharmaceutically acceptable salt thereof, wherein:
- A is 0;
- P is Rc—C(O)—;
- Rc is RD;
- RD is 2,5-dichlorophenyl;
- Ra is isobutyl;
- Ra1 is hydrogen;
- each Rb1 and Rb2 independently is hydrogen;
- each Rb3 and Rb4 independently is —(CH2)p—CO2H;
- wherein one of carboxylic acids optionally forms a further bond with the boron atom;
- p is 0 or 1;
- n is 0 or 1;
- and
- the cancer is multiple myeloma, recurrence of multiple myeloma, lymphoma, or recurrence of lymphoma.
Dependencies are inferred from the claim text.