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US 9,175,015 B2Granted
Gold nanoparticle conjugates and uses thereof
AssigneeColorado School of Mines
InventorsStephen G. Boyes, Misty D. Rowe, Jay Hotchkiss
Life of this patent
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Abstract
The disclosure generally relates to formation of polymers grafted to or polymerized from the surface of gold nanoparticles. The polymers are functionalized to include therapeutic agents and/or targeting agents at their surface, thereby allowing both therapeutic and targeting compounds to be directed to specific cells in a patient.
Claims12
A gold nanoparticle conjugate comprising a polymer grafted onto a gold nanoparticle, the gold nanoparticle having the structure of Formula (II):
- wherein R1, R2, R3, and R4 are
- each independently selected from hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, acyl, substituted acyl, acylamino, substituted acylamino, alkylamino, substituted alkylamino, alkylsulfinyl, substituted alkylsulfinyl, alkylsulfonyl, substituted alkylsulfonyl, alkylthio, substituted alkylthio, alkoxycarbonyl, substituted alkoxycarbonyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, aryloxy, substituted aryloxy, aryloxycarbonyl, substituted aryloxycarbonyl, carbamoyl, substituted carbamoyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, dialkylamino, substituted dialkylamino, halo, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heteroalkyloxy, substituted heteroalkyloxy, heteroaryloxy and substituted heteroaryloxy;
- represents the surface of a gold nanoparticle grafted to the polymer under non-reducing conditions and through more than one sulfur atom.
Dependencies are inferred from the claim text.