Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6H)-ones

A compound of Formula II:

• or a pharmaceutically acceptable salt thereof, wherein
• X and Y are independently nitrogen or carbon, but at least one is nitrogen;
• M =0-4;
• each occurrence of R1 and R2 is independently selected from H, halo, aryl, heteroaryl, heterocycle, —(C1-C6 alkyl) aryl, —(C1-C6 alkyl) heteroaryl, —CN, C1-C6 alkyl, C1-C6 thioalkyl, C1-C6 thiohaloalkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, —OH, C1-C6 alkoxy, C1-C6 haloalkoxy, —NO2, —SO2C1-C6 alkyl, —SOC1-C6 alkyl, —SO2NH(C1-C6 alkyl), —SO2N(C1-C6 alkyl)2, —CONH(C1-C6 alkyl), —CON(C1-C6 alkyl)2, —C(O)O(C1-C6 alkyl), —C(O)O(C1-C6 alkyl)aryl, —OC(O)(C1-C6 alkyl), —OC(O)(C1- C6 alkyl)aryl, —SO2NH2, —CONH2, —CO2H, —COH, —NH2, C1-C6 alkylamino, di-C1-C6 alkylamino, —N3, cyanate, isocyanate, thiocyanate, isothiocyanate, —(C2-C6 alkenyl)O(C1-C6 alkyl), —(C1-C6 alkyl)O(C1-C6 alkyl), —(C1-C6 alkyl)O(C1-C6 alkyl)O(C1-C6 alkyl), aryloxy, arylthio, —CO(C1-C6 alkyl), —CO(aryl), —CO(heteroaryl), and —CO(heterocycle);
• or R1 and R2 are on adjacent carbons and taken together with the carbons to which they are attached form a 5-6 member saturated or unsaturated monocylic ring system comprising one or more oxygen or nitrogen atoms, wherein the ring system is optionally substituted with one or more groups selected from halo, C1-C6 alkyl, C1-C6 alkoxy, and C1-C6 haloalkoxy;
• R3 and R4 are independently selected from H, halo, —CN, C1-C6 alkyl, C1-C6 haloalkyl, OH, C1-C6 alkoxy, C1-C6 haloalkoxy, aryl, heteroaryl, —(C1-C6 alkyl) aryl, —(C1-C6 alkyl) heteroaryl, heterocycle, —NO2, —SO2C1-C6 alkyl, —SO2N(C1-C6 alkyl)2, —CONH(C1-C6 alkyl), —CON(C1-C6 alkyl)2;
• —(CR7R8)0-3NR5R6;
• or R3 and R4 taken together with the carbons to which they are attached form a 5-6 member monocylic ring system comprising one or more oxygen atoms;
• R5, R6, R7, and R8 are independently selected from H, F, C1-C6 alkyl, C1-C6 haloalkyl, OH, C1-C6 alkoxy, —C1-C6 haloalkoxy, —SO2C1-C6 alkyl, —SO2N(C1-C6 alkyl)2, —CO2(C1-C6 alkyl), —CO2CH2C6H5, —CONH(C1-C6 alkyl), and —CON(C1-C6 alkyl)2, or optionally R5 and R6 and the nitrogen to which they are attached form a ring taken from azetidine, pyrollidine, piperidine, homopiperidine, morpholine, morpholinone, homomorpholine, homomorpholinone, piperazine, piperazinone, homopiperazine and homopiperazinone with the ring optionally substituted with up to three independent occurrences of R1;
• or any two of R5, R6, R7, and R8 taken together with the atoms to which they are attached form a 3-7 member monocyclic ring containing up to two heteroatoms selected from nitrogen, oxygen, and sulfur.