Back to results
US 9,175,005 B2Granted
Crystalline hydrochloride salt of darunavir
AssigneeHetero Research Foundation
InventorsBandi Parthasaradhi Reddy, Kura Rathnakar Reddy, Dasari Muralidhara Reddy, Rapolu Raji Reddy, Bandi Vamsi Krishna, Kesireddy Subash Chander Reddy
Life of this patent
Estimating the term…
Abstract
The present invention provides novel crystalline hydrochloride salt of darunavir, process for its preparation and to pharmaceutical composition comprising it. The present invention also provides novel process for preparation of darunavir amorphous form and pharmaceutical composition comprising it.
Claims11
A process for the preparation of darunavir amorphous form, comprising
- a. dissolving a crystalline hydrochloride salt of darunavir in an organic solvent and water to form a reaction mass;
- b. adjusting the pH of the reaction mass to about 7.0 to 8.5 with a base to form a solution;
- c. removing the organic solvent from the solution obtained in step (b) to provide a residual mass;
- d. slurrying the residual mass obtained in step (b) with an aliphatic hydrocarbon solvent or an aromatic solvent;
- and
- e. isolating darunavir amorphous form.
3 more elements
Dependencies are inferred from the claim text.