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US 9,174,995 B2Granted
Pyrrolotriazinone derivatives
AssigneeMerck Patent GmbH
InventorsDieter Dorsch, Hans-Peter Buchstaller
Life of this patent
Estimating the term…
Abstract
Compounds of the formula I in which X, R1 and Y have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
Claims25
A compound selected from the following group:
- No.
- Name
- “A1”
- 2-p-tolyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one
- “A2”
- 4-(4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-benzoic
- acid methyl ester
- “A3”
- 2-(4-tert-butyl-phenyl)-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one
- “A4”
- 2-(1-acetyl-piperidin-4-yl)-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one
- “A5”
- 2-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-3H-pyrrolo-
- [2,1-f][1,2,4]triazin-4-one
- “A6”
- 2-(4-bromo-phenyl)-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one
- “A7”
- 2-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-3H-pyrrolo-
- [2,1-f][1,2,4]triazin-4-one
- “A8”
- 2-(4-pyrrolidin-l-ylphenyl)-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one
- “A9”
- 2-cyclohexyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one
- “A10”
- 2-(1-tert-butylpyrazol-4-yl)-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one
- “A11”
- 2-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-3H-pyrrolo
- [2,1-f][1,2,4]triazin-4-one
- “A12”
- 6-fluoro-2-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-3H-pyrrolo
- [2,1-f][1,2,4]triazin-4-one
- “A13”
- 6-methyl-2-[4-(1-methylpyrazol-4-yl)phenyl]-3H-pyrrolo-
- [2,1-f][1,2,4]triazin-4-one
- “A14”
- 2-[4-(1-ethyl-1-hydroxy-propyl)-phenyl]-3H-pyrrolo[2,1-
- f][1,2,4]triazin-4-one
- “A15”
- 2-{4-[1-(2-hydroxy-ethoxy)-1-methyl-ethyl]-phenyl}-3H-
- pyrrolo[2,1-f][1,2,4]triazin-4-one
- “A16”
- 2-[4-(1-amino-1-methyl-ethyl)-phenyl]-3H-pyrrolo[2,1-f][1,2,4]-
- triazin-4-one
- “A17”
- 6-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-2-methyl-5H-1,5,7,7a-
- tetraaza-inden-4-one
- “A18”
- 6-chloro-2-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-3H-pyrrolo
- [2,1-f][1,2,4]triazin-4-one
- “A19”
- 2-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-7-methyl-3H-
- pyrrolo[2,1-f][1,2,4]triazin-4-one
- “A20”
- 2-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-7-trifluoromethyl-3H-
- pyrrolo[2,1-f][1,2,4]triazin-4-one
- “A21”
- 2-[4-(1-hydroxy-cyclopentyl)-phenyl]-3H-pyrrolo[2,1-f][1,2,4]-
- triazin-4-one
- and pharmaceutically acceptable solvates, salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.
56 more elements
Dependencies are inferred from the claim text.