2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purines as antiviral agents

A method of reducing viral replication in a mammal infected with a virus selected from the group consisting of a cytomegalovirus (CMV), herpes simplex virus-1 (HSV-1), herpes simplex virus-2 (HSV-2), human herpes virus-6 (HHV-6), human herpes virus-7 (HHV-7), human herpes virus-8 (HHV-8), and hepatitis B virus (HBV) comprising the step of administering to said mammal an effective amount of:

• a compound having Formula 1 or Formula 2:
• wherein B is 2-aminopurine-9-yl, unsubstituted or substituted at the 6 position with NHR1, OR2, or SR3;
• R1 is selected from the group consisting of alkenyl, alkynyl, and benzyl, any of which may be optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl;
• R2 is selected from the group consisting of alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl, and aryl;
• and
• R3 is selected from the group consisting of alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl;
• or
• a compound having Formula 3 or Formula 4:
• wherein X is O;
• R1 and R2 are alkyl or aryl;
• or R1X or R2X is an amino acid residue with X as NH;
• B is 2-aminopurine-9-yl, which is unsubstituted or substituted at the 6 position with NHR4, OR5, or SR6;
• R4 is selected from the group consisting of alkenyl, and alkynyl, any of which may be optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl;
• R5 is selected from the group consisting of alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl;
• R6 is selected from the group consisting of alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl;
• or a combination thereof.