Chemical compounds

A compound of the following formula:

• wherein:
• Y represents CH or N;
• Z represents CR1 or N;
• R1 represents hydrogen, halogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylaryl, alkylheterocyclyl, alkylheteroaryl, wherein cycloalkyl, heterocyclyl, aryl, heteroaryl, at each occurrence, may be optionally substituted by one or more Rc groups;
• D represents C═O, C═S, C≡N—C≡N, C≡N═NO2, or C≡N═SO2Me;
• L represents
• or -Q9-(CRaRb)n-Q10-, wherein the ring systems of L may be optionally substituted by one or more Rc groups;
• Q1 represents CR2R3, NR4, NR4CR2R3 or O;
• R2, R3 and R4 independently represent hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, wherein alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, at each occurrence, may be optionally substituted by one or more Rc groups;
• R2 and R3 together with the carbon atom to which they are attached may form a carbocyclic or heterocyclic ring which may be optionally substituted by one or more Rc groups;
• Q2 is absent or represents CR2R3, NR4, NR4CR2R3 or O;
• R2, R3 and R4 independently represent hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, wherein alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, at each occurrence, may be optionally substituted by one or more Rc groups;
• R2 and R3 together with the carbon atom to which they are attached may form a carbocyclic or heterocyclic ring which may be optionally substituted by one or more Rc groups;
• Q3 and Q4 independently represent CR5 or N;
• R5 represents hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, wherein cycloalkyl, heterocyclyl, aryl, heteroaryl, at each occurrence may be optionally substituted by one or more Rc groups;
• p and q independently represent an integer selected from 0 to 4, such that the sum of integers for p and q do not exceed 5;
• Q5 represents CR6R7, NR8, NR8CR6R7 or O;
• R6, R7 and R8 independently represent hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, wherein cycloalkyl, heterocyclyl, aryl, heteroaryl, at each occurrence, may be optionally substituted by one or more Rc groups;
• R6 and R7 together with the carbon atom to which they are attached may form a carbocyclic or heterocyclic ring which may be optionally substituted by one or more Rc groups;
• Q6 represents CR9 or N;
• R9 represents hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, wherein cycloalkyl, heterocyclyl, aryl, heteroaryl, at each occurrence, may be optionally substituted by one or more Rc groups;
• Q7 and Q8 are independently CR10R11, NR12 or O;
• R10, R11 and R12 independently represent hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, wherein cycloalkyl, heterocyclyl, aryl, heteroaryl, at each occurrence, may be optionally substituted by one or more Rc groups;
• R10 and R11 together with the carbon atom to which they are attached may form a carbocyclic or heterocyclic ring which may be optionally substituted by one or more Rc groups;
• Q9 and Q10 independently represent CR14R15, NR16, CR14R15NR16 or O;
• Ra and Rb independently represent hydrogen, alkyl or alkenyl;
• R14, R15 and R16 independently represent hydrogen, alkyl, amino, alkenyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, wherein cycloalkyl, heterocyclyl, aryl, heteroaryl, at each occurrence, may be optionally substituted by one or more Rc groups;
• R14 and R15 together with the carbon atom to which they are attached may form a carbocyclic or heterocyclic ring which may be optionally substituted by one or more Rc groups;
• n represents an integer selected from 0 to 5;
• M is absent or represents
• or —CO—R22;
• M1, M2, M3, M4 and M5 independently represent CH or N;
• R18, R19 and R20 independently represent hydrogen, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, wherein cycloalkyl, heterocyclyl, aryl, heteroaryl, at each occurrence, may be optionally substituted by one or more Rc groups;
• R21 represents hydrogen, F, Cl, CF3, NH2, NO2, thiazolyl or pyridyl;
• r represents an integer selected from 0 to 3;
• R22 represents alkyl, hydroxyl, alkanol, alkoxy, haloalkyl or aminoalkyl;
• Rc represents halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —(CH2)0-4—C3-8 cycloalkyl, —(CH2)0-4—C3-8 cycloalkenyl, —(CH2)0-4-phenyl, —(CH2)0-4-(heterocyclyl), —(CH2)0-4-(heteroaryl), —(CRxRy)0-4—O—Rz, —O—(CRxRy)1-4—ORz, haloC1-6 alkyl, haloC1-6 alkoxy, C1-6 alkanol, ═O, ═S, nitro, Si(Rx)4, —(CH2)0-4—CN, —S(O)0-2—Rx, —C(═O)Rx, —(CRxRy)0-4—C(═O)ORz, —(CRxRy)0-4—O—C(═O)—Rz, —(CRxRy)0-4—C(═O)NRxRy, —(CH2)0-4—NRxC(═O)Ry, —(CH2)0-4—OC(═O)NRxRy, —(CH2)0-4—NRxC(═O)ORy, —(CH2)0-4—NRxRy, —NRx—(CH2)0-4—Rz, —(CH2)0-4—O—C(═O)—C1-4alkyl-NRxRy, —(CH2)0-4—NRx—(CH2)1-4—O—C(═O)—Rz, —(CH2)0-4—NRx—(CH2)0-4—SO2—Ry, —(CH2)0-4—NH—SO2—NRxRy, —(CH2)0-4—SO2NRxRy and —P(═O)(Rx)2 groups;
• Rx, Ry and Rz independently represent hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —(CH2)0-4—C3-8 cycloalkyl, —(CH2)0-4—C3-8 cycloalkenyl, —(CH2)0-4-(heterocyclyl), —(CH2)0-4-(heteroaryl), C1-6 alkanol optionally substituted with one or more halo, —C(═O)OC1-6 alkyl, hydroxy, C1-6 alkoxy, haloC1-6 alkyl, —(CH2)1-4—O—C1-6alkyl, —C(═O)—(CH2)1-4—C1-6 alkoxy, —C(═O)—C1-6alkyl, —(CH2)0-4—CN, C1-6 alkyl-N(H)2-s(C1-6alkyl)s, —N(H)2-s(C1-6alkyl)s, —C(═O)—N(H)2-s(C1-6alkyl)s, —(CH2)0-4—NH—SO2—N(H)2-s (C1-6alkyl)s, —(CH2)0-4—N(C1-4alkyl)-SO2—N(H)2-s(C1-6alkyl)s and —(CH2)0-4—O—C(═O)—C1-4alkyl-N(H)2-s(C1-6alkyl)s, and when attached to nitrogen or carbon or phosphorus or silicon atom Rx and Ry may join to form a 3-7 membered ring optionally containing a one or two heteroatoms selected from O, N, S and oxidised forms of N or S;
• and
• s represents an integer selected from 0 to 2;
• provided that when Q2 is absent, M is absent;
• or a pharmaceutically acceptable salt thereof.