Heterocyclic compounds as inhibitors of leukotriene production

A compound of formula I, wherein:

• A is carbon;
• R1 and R2 together with the carbon atom to which they are attached form a C3-10 carbocyclic ring, wherein each carbocycle is optionally independently substituted with one to two groups selected from C1-6 alkyl and halogen;
• R3 is a 5-11 membered heteroaryl ring containing one to three nitrogen, wherein the heteroaryl ring is optionally independently substituted with one to three groups selected from C1-5alkyl, —O—C1-5alkyl, C1-3 alkylhydroxy, halogen, hydroxy, amino, C1-6 alkylamino and C1-3 dialkylamino;
• R4 is hydrogen, C1-3 alkyl, halogen or nitrile;
• HET is indolyl
• R5, R6 and R7 are each independently selected from
• (a) —H,
• (b) —OH,
• (c) halogen,
• (d) —CN,
• (e) C1-6alkyl optionally substituted with one to three —OH, —O—C1-6alkyl, —N(R8)(R9), —O—C1-6alkyl-OH, —CO2R8, —C(O)N(R8)(R9) or —S(O)nC1-6alkyl, aryl optionally substituted with halogen, 5-11 membered heteroaryl ring optionally substituted with C1-4 alkyl-OH, 3-8 membered heterocycle optionally substituted with C1-4 alkyl,
• (f) —O—C1-6alkyl optionally substituted with 5-11 membered heteroaryl ring,
• (g) —O-heterocycle
• (h) —N(R8)(R9),
• (i) —S(O)nC1-6alkyl,
• (j) —S(O)naryl,
• (k) —CO2R8,
• (l) —C(O)N(R8)(R9),
• (m) —S(O)2N(R8)(R9),
• (n′) oxo,
• (o) —C(O)—C1-3 alkyl
• (p) C3-10 carbocycle,
• (q) a 3-10 membered heterocyclic group optionally substituted with one to three C1-6 alkyl groups,
• (r) a 5-11 membered heteroaryl group optionally substituted with one to three substituents selected from C1-4 alkyl, C1-4 alkyl-OH, —O—C1-4 alkyl, C1-4 alkyl-N(R8)(R9), C1-4 alkyl-C(O)N(R8)(R9), —N(R8)(R9) and halogen,
• (s) aryl optionally substituted with halogen;
• R8 and R9 are each independently selected from —H, —C1-6alkyl, —C(O)C1-6alkyl, and a 3-6 membered heterocyclic group, each of which is optionally independently substituted with one to three C1-6alkyl groups, —OH, —C(O)N(R10)(R11), —S(O)nC1-6alkyl, —S(O)nN(R10)(R11), CN, a 3-6 membered heterocyclic group which is optionally substituted with one to two groups selected from C1-3 alkyl, —OC1-6alkyl, and oxo;
• or
• R8 and R9 taken together with the nitrogen ring to which they are attached form a heterocyclyl ring optionally substituted with one to three —OH, CN, —OC1-6alkyl or oxo;
• R10 and R11 are each independently selected from —H and —C1-6alkyl;
• n is 0, 1 or 2;
• or a pharmaceutically acceptable salt thereof.