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US 9,174,978 B2Granted
Monobactam organic compounds for the treatment of bacterial infections
AssigneeNovartis AG
InventorsVirender Singh Aulakh, Anthony Casarez, Xiaodong Lin, Mika Lindvall, Glenn McEnroe, Heinz Ernst Moser, Folkert Reck, Meiliana Tjandra, Robert Lowell Simmons, Aregahegn Yifru, Qingming Zhu
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Abstract
This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.
Claims24
A compound of Formula (IA):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- Z is CH;
- the group —O—CR1R2R3 is selected from
- and
- Het is selected from
3 more elements
Dependencies are inferred from the claim text.