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US 9,174,974 B2Granted
Macrocyclic factor VIIa inhibitors
AssigneeBristol-Myers Squibb Company
InventorsXiaojun Zhang, Peter Glunz, Eldon Scott Priestley, James A. Johnson, Nicholas Ronald Wurtz, Vladimir Ladziata
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Abstract
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.
Claims9
A compound of Formula (I):
- or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:
- W is
- wherein the ring moiety is substituted with 0-2 F atoms;
- L is independently selected from:
- CH(C1-2 alkyl), CF2, CH(CH2F), CH(CHF2), and CH2CH(OH);
- R1 and R2 are independently selected from:
- H, C1-2 alkyl and C1-2 alkoxy;
- R4 and R9 are independently selected from:
- H, F and Cl;
- and
- R8 is independently selected from:
- —O(CH2)1-4O(C1-4 alkyl), —CON(C1-4 alkyl)2, —SO2(C1-6 alkyl), —SO2(cyclopropyl), —P(═O)(OC1-4 alkyl)2,
9 more elements
Dependencies are inferred from the claim text.