US 9,174,972 B2 · Cognition enhancing compounds and compositions, methods of making, and methods of treating

Abstract

The invention relates generally to muscarinic agonists, which are useful for stimulating muscarine receptors, and treating cognitive disorders. Included among the muscarinic agonists disclosed herein are oxadiazole derivatives, compositions, and preparations thereof. Methods of synthesizing oxadiazole compounds also are provided. This disclosure also relates in part to compositions for enhancing cognitive function in subjects such as humans, the compositions comprising a muscarinic agonist or a pharmaceutically suitable form thereof. This disclosure relates in part to methods of treating animals such as humans by administering such compositions.

Claims10

Dependent claims

A M1 or M1/M4 selective muscarinic agonist compound of Formula XI, a stercoisomer thereof or a pharmaceutically acceptable salt of said compound or stereoisomer, wherein the compound has the structure:

wherein
X is O or S;
R1 is NH2, a C1-6 alkyl group or a C3-6 cycloalkyl group, wherein the alkyl or cycloalkyl groups are optionally substituted with 1 or more Deuterium (“D”);
R2, R2b, R4a, R4b, R5, R6a and R6b are independently selected from H or D;
and
R3 is H, D or an amino-protecting group.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/791,251Filed 8 Mar 2013 · continuation

Priority

8 Sep 2010

Published

US 2013/0274299 A117 Oct 2013

Granted

3 Nov 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07D 413/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
C07B 59/002
Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se: heterocyclic compounds
C07D 403/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
C07D 417/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond

Cognition enhancing compounds and compositions, methods of making, and methods of treating

Life of this patent

Cognition enhancing compounds and compositions, methods of making, and methods of treating

Life of this patent

Abstract

Claims10