Pyrimidinylpiperidinyloxypyridone analogues as GPR119 modulators
AssigneeBristol-Myers Squibb Company
InventorsMatthias Broekema, Gang Wu, Dean A. Wacker
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Abstract
Novel compounds of structure Formula I: (I) or an enantiomer, a diastereomer, or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are defined herein, are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the GPR119 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.
Claims13
A compound of formula I
- enantiomer, diastereomer, tautomer, or salt thereof wherein:
- R1 is hydrogen or halo;
- R2 is (C1-C10)alkyl;
- and
- R3 is halo or (C1-C10)alkyl.
A compound or salt thereof, having the formula:
A compound or salt thereof, having the formula:
Dependencies are inferred from the claim text.