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US 9,174,960 B2Granted
Compounds useful against kinetoplastideae parasites
AssigneeCentre National De La Recherche Scientifique
InventorsElisabeth Davioud-Charvet, Ingrid Nicole Wenzel, Thomas J. J. Müller, Gilles Hanquet, Don Antoine Lanfranchi, Frédéric Leroux, Thibault Gendron
Life of this patent
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Abstract
Dibenzylidene and heterobenzylideneacetone derivatives, related 4-piperidones, related 4-thiopyranones and the corresponding sulfinyl- and sulfonyl-analogues for their use for prophylaxis or treatment of trypanosomiasis and leishmaniasis.
Claims10
A method of treating infection caused by a kinetoplastidae parasite, comprising administering to a mammal in need thereof an effective amount of at least one compound according to formula (I)
- wherein
- A is
- with W representing S(O)p with p=0 to 2,
- B and D each independently of each other represent an aryl group or a heteroaryl group optionally substituted by one to 5 substituents selected from the group consisting of:
- hydrogen atom,
- halogen atoms,
- hydroxy group,
- linear (C1-C4)alkyl groups or branched (C3-C4)alkyl groups,
- (C1-C4) alkoxy groups,
- (C1-C4) thioalkoxy groups,
- trifluoromethyl group,
- trifluoromethoxy group,
- pentafluorosulfanyl group,
- acetamide group,
- —OC(O)C6H5,
- formyl group,
- —COOH,
- —COOR with R representing a (C1-C4)alkyl group,
- —CH2OH,
- —CH2OR′ with R′representing a (C1-C4)alkyl group, —CH2OCH3 or a protecting group forming an acetal,
- —NH2,
- —NR2 with R representing a (C1-C4)alkyl group,
- —NO2,
- —CN, and
- and the pharmaceutically acceptable salts thereof.
22 more elements
Dependencies are inferred from the claim text.