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US 9,174,959 B2Granted
Process for preparation of dronedarone by N-butylation
AssigneeSanofi
InventorsAntal Friesz, Zsolt Párkányi, Zsolt Dombrády
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Abstract
The invention relates to a novel process for preparation of dronedarone (I) and pharmaceutically acceptable salts thereof where the compound of formula (II) or salt thereof is reacted with a compound of formula L-(CH2)3—CH3 (III), where L is a leaving group, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and the preparation thereof.
Claims4
A process for preparing dronedarone (I) or pharmaceutically acceptable salts thereof
- comprising reacting a compound of formula (II) or a salt thereof
- with a compound of formula L−(CH2)3−CH3(III), where L is a leaving group,
- and isolating the obtained product and, optionally, converting into a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.