Process for the preparation of dronedarone
AssigneeSanofi
InventorAntal Friesz
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Abstract
This disclosure relates to a process for the preparation of N-[2-n-butyl-3-{4-[(3-dibutylamino)-propoxy]-benzoyl}-1-benzofuran-5-yl]-methane-sulfonamide of formula I and its pharmaceutically acceptable salts, wherein one of the methylsulfonyl groups of the 2-n-butyl-3-[(di-n-butylamino-3-propoxy)-benzoyl]-5-bis-(methylsulfonamido)-benzofuran of formula II is selectively cleaved and if desired, the resulting compound of formula I is transformed into its salt.
Claims17
A process for the preparation of N-[2-n-butyl-3-{4-[(3-dibutylamino)-propoxy]-benzoyl}-1-benzofuran-5-yl]-methane-sulfonamide of formula I:
- or a pharmaceutically acceptable salt thereof,
- comprising selectively cleaving in the presence of alkali alcoholate, one of the methylsulfonyl groups of the 2-n-butyl-3-[(di-n-butylamino-3-propoxy)-benzoyl]-5-bis-(methylsulfonamido)-benzofuran of formula II:
- and if desired, transforming the resulting compound of formula I into its salt.
The compound 2-n-butyl-3-(4-hydroxy-benzoyl)-5-bis-(methylsulfonamido)-benzofuran of formula VI:
The compound 2-n-butyl-5-bis-(methylsulfonamido)-3-(4-methoxy-benzoyl)-benzofuran of formula VII:
Dependencies are inferred from the claim text.