Back to results
US 9,174,941 B2Granted
Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
AssigneeReata Pharmaceuticals, Inc.
InventorsEric Anderson, Gary L. Bolton, Bradley Caprathe, Xin Jiang, Chitase Lee, William H. Roark, Melean Visnick
Life of this patent
Estimating the term…
Abstract
Disclosed herein are novel antioxidant inflammation modulators, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.
Claims7
A compound of the formula:
- wherein:
- R1 and R2 are each methyl;
- R3 is hydrogen;
- and
- R4 is:
- hydrogen;
- or
- alkyl(C≦12), alkenyl(C≦12), alkynyl(C≦12), aryl(C≦12), aralkyl(C≦12), hetero-aryl(C≦12), acyl(C≦12) or a substituted version of any of these groups, wherein one or more hydrogen atom has been independently replaced by —OH, —F, —Cl, —Br, —I, —NH2, —NO2, —CO2H, —CO2CH3, —CN, —SH, —OCH3, —OCH2CH3, —C(O)CH3, —N(CH3)2, —C(O)NH2, —OC(O)CH3, or —S(O)2NH2;
- or a pharmaceutically acceptable salt or tautomer thereof.
6 more elements
Dependencies are inferred from the claim text.