Transition metal complexes of bis[thiohydrazide amide] compounds
AssigneeSynta Pharmaceuticals Corp.
InventorsMasazumi Nagai, Jianhua Shen
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Abstract
The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I), or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. In one embodiment, the compound is represented by Structural Formula (II), or a prodrug, isomer, ester, salt, hydrate, solvate or polymorph thereof. The present invention also provides a pharmaceutical composition comprising the compound of the invention and method of use thereof.
Claims24
A compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by the following Structural Formula:
- wherein:
- R1-R4 are independently —H, an optionally substituted aliphatic group, an optionally substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aryl group;
- and
- Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group, or Y, taken together with both >C═Z groups to which it is bonded, is a substituted or unsubstituted aryl group;
- R7 and R8 are independently —H, an optionally substituted aliphatic group, or an optionally substituted aryl group;
- and
- each Z is independently O or S.
A compound comprising a bis[thiohydrazide amide] complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by the following Structural Formula:
- wherein:
- R1-R4 are independently —H, an optionally substituted aliphatic group, an optionally substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aryl group;
- and
- Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group, or Y, taken together with both >C═Z groups to which it is bonded, is a substituted or unsubstituted aryl group;
- R7 and R8 are independently —H, an optionally substituted aliphatic group, or an optionally substituted aryl group;
- and
- each Z is independently O or S.
Dependencies are inferred from the claim text.