Compositions for the treatment of diabetes and pre-diabetes
AssigneeCellix Bio Private Limited
InventorMahesh Kandula
Life of this patent
Estimating the term…
Abstract
The invention relates to the compositions of formula I or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprises a salt of metformin and the methods for treating or preventing metabolic syndrome, prediabetes and diabetes may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of diabetes mellitus, obesity, lipid disorders, hypertriglyceridemia, hyperglycemia, hyperinsulinemia and insulin resistance.
Claims8
A composition comprising Formula I,
- with one of:
- at least one polyunsaturated fatty acid molecular conjugate represented by RH and a mixture of metformin in a pharmaceutically acceptable salt form and the at least one polyunsaturated fatty acid molecular conjugate represented by RH,
- wherein,
- R1, R2, R3, and R4 each independently represents one of:
- H, D, CD3 and CH3,
- RH independently represents
A composition comprising Formula I,
- with one of:
- at least one polyunsaturated fatty acid molecular conjugate represented by RH and a mixture of metformin in a pharmaceutically acceptable salt form and the at least one polyunsaturated fatty acid molecular conjugate represented by RH,
- wherein,
- R1, R2, R3, R4 each independently represents one of:
- H, D, CD3 and CH3, and
- RH represents the at least one polyunsaturated fatty acid molecular conjugate, and is independently selected from the group consisting of:
- a molecular conjugate of eicosapentaenoic acid, D-pantothenic acid and salsalate,
- a molecular conjugate of eicosapentaenoic acid, D-pantothenic acid and 2-((2-acetoxybenzoyl)oxy)benzoic acid,
- a molecular conjugate of eicosapentaenoic acid, D-pantothenic acid and nicotinic acid,
- a molecular conjugate of eicosapentaenoic acid, D-pantothenic acid and hydroxytyrosol,
- a molecular conjugate of eicosapentaenoic acid, D-pantothenic acid and R-lipoic acid,
- a molecular conjugate of eicosapentaenoic acid and fumaric acid, and
- a molecular conjugate of eicosapentaenoic acid, D-pantothenic acid.
Dependencies are inferred from the claim text.