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US 9,174,904 B1Granted
Synthesis of 2,2-bis(3-phenyl-4-hydroxyphenyl) propane (PHP)
AssigneeSabic Global Technologies B.V.
InventorsGirish Chandra, Meerakani Mohamed Ali Sait, Akhilesh Tanwar, Sharankumar Shetty
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Abstract
Disclosed herein are ortho aryl substituted bisphenol monomers that exhibit a lower binding energy to estradiol related receptors. The monomers are provided by the condensation of a ketone and phenol in the presence of an acid catalyst.
Claims14
A method for preparing an ortho aryl substituted bisphenol monomer comprising:
- reacting a ketone and a phenol in the presence of an acid catalyst and a 3-mercaptopropionic acid to produce an aromatic dihydroxy compound, wherein the aromatic dihydroxy compound is an ortho aryl substituted bisphenol monomer, and wherein the aromatic dihydroxy compound has a lower binding energy than the binding energy of estradiol to the ligand binding domain cavity of an estradiol related receptor comprising ERR-α.
A method for preparing an ortho aryl substituted bisphenol monomer as represented by Formula I:
- where R1 and R2=phenyl,
- comprising:
- reacting a compound represented by Formula II:
- with a compound represented by Formula III:
- in the presence of an acid catalyst and a promoter.
2 more elements
Dependencies are inferred from the claim text.