Method for storing and delivering a drug
AssigneeByeong S. Chang
InventorsByeong Seon Chang, Roger Wongjung Liu
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Abstract
A container closure delivery system that is suitable for lyophilized pharmaceutical injectable powder products is disclosed. The system comprises storage stable powder formulations and a container closure assembly design wherein the formulation can be filled and lyophilized with a standard fill finish equipment, and the formulations and lyophilization processes are optimized to produce a powder that readily dissolves upon contact with a diluent, thereby facilitating the direct injection of the lyophilized product without the need for a separate reconstitution/mixing/priming step.
Claims20
A method of dispensing of a lyophilized pharmaceutical product, the method comprising the step of forcing a diluent through a container closure delivery system comprising the lyophilized pharmaceutical product in order to contact the diluent with the lyophilized pharmaceutical product in a manner that causes rapid dissolving of the lyophilized pharmaceutical product,
- wherein the dissolved pharmaceutical product exits the container closure delivery system in an essentially constant gradient with more highly concentrated dissolved pharmaceutical product exiting first, and
- wherein the method does not require a separate reconstitution, mixing, and/or priming step to dissolve the lyophilized pharmaceutical product with the diluent.
Dependencies are inferred from the claim text.