System for blood separation with replacement fluid apparatus and method

A method of providing a controlled amount of blood replacement fluid to a blood donor comprising:

• providing a disposable blood processing set for use on a centrifugal blood processing device, said disposable set comprising:
• a blood separation chamber adapted to be mounted on a rotor of said centrifugal blood processing device;
• a blood inlet line adapted to be coupled to a blood donor and to an inlet pump on said centrifugal blood processing device;
• an anti-coagulant line in fluid communication with said inlet line, said anti-coagulant line being adapted to be fluidly coupled to a supply of anti-coagulant and being further adapted to be coupled to an anti-coagulant pump on said centrifugal blood processing device;
• a reservoir adapted to be coupled to at least one sensor for detecting a level of fluid in said reservoir;
• a return line in fluid communication with said reservoir, said return line being adapted to be coupled to said blood donor and to a return pump on said centrifugal blood processing device;
• a red blood cell line in fluid communication with said blood separation chamber and said reservoir;
• a collect line in fluid communication with said blood separation chamber and in selective communication with said reservoir and a collect bag, said collect line being adapted to be coupled to a collect pump;
• a plasma line in fluid communication with said blood separation chamber and with said reservoir, said plasma line being adapted to be coupled to a plasma pump;
• and
• a replacement fluid line in fluid communication with said reservoir and adapted to be placed in fluid communication with a source of replacement fluid;
• mounting said disposable blood processing set on said centrifugal blood processing device;
• removing whole blood from said donor through said inlet line;
• providing anti-coagulant to said whole blood in said inlet line;
• measuring the flow of said whole blood and said anti-coagulant in said inlet line;
• separating said whole blood and said anti-coagulant into a plurality of blood components in said separation chamber;
• flowing red blood cells from said separation chamber into said reservoir;
• flowing a first blood component from said separation chamber into said reservoir;
• measuring the flow of said first blood component into said reservoir;
• removing a second blood component from said separation chamber;
• measuring the flow of said second component;
• selectively flowing at least part of said second component into said reservoir;
• selectively flowing replacement fluid into said reservoir;
• periodically flowing contents of said reservoir into said return line;
• measuring the flow of said contents;
• determining a quantity of replacement fluid delivered to said donor from said measured inlet line flow, first blood component flow, collect flow and return flow.