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US 9,173,978 B2Granted
Bioabsorbable polymeric compositions, processing methods, and medical devices therefrom
AssigneeEthicon, Inc.
InventorsBrian M. Kelly, Dennis D. Jamiolkowski, Christopher DeFelice
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Abstract
Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Claims65
A bioabsorbable melt polymer blend, comprising:
- 78 weight percent to 82 weight percent of a first bioabsorbable polymer and 18 weight percent to 22 weight percent of a second bioabsorbable polymer,
- the first bioabsorbable polymer comprising a lactide-rich polymer comprising about 95 mol percent to about 70 mol percent polymerized lactide and about 5 mol percent to about 30 mol percent polymerized glycolide, and the second bioabsorbable polymer comprising poly(p-dioxanone),
- wherein the polymer blend has a maximum weight percent of poly(p-dioxanone) of 22 weight percent and a minimum weight percent of poly(p-dioxanone) that depends upon the molar amount of polymerized lactide in the lactide-rich polymer and is calculated by the expression:
- Minimum Weight Percent Poly(p-dioxanone)=(215.6212/Mol Percent Polymerized Lactide)2.7027
- and wherein the polymer blend provides dimensional stability to a manufactured article.
2 more elements
A thermally processed bioabsorbable polymer blend, comprising:
- 78 weight percent to 82 weight percent of a first bioabsorbable polymer and 18 weight percent to 22 weight percent of a second bioabsorbable polymer, the first bioabsorbable polymer comprising a lactide-rich polymer comprising 95 mol percent to about 70 mol percent polymerized lactide and 5 mol percent to 30 mol percent polymerized glycolide, and the second bioabsorbable polymer comprising poly(p-dioxanone),
- wherein the polymer blend has a maximum weight percent of poly(p-dioxanone) of 22 weight percent and a minimum weight percent of poly(p-dioxanone) that depends upon the molar amount of polymerized lactide in the lactide-rich polymer and is calculated by the expression:
- Minimum Weight Percent Poly(p-dioxanone)=(215.6212/Mol Percent Polymerized Lactide)2.7027
- and wherein the polymer blend provides dimensional stability to a manufactured article.
1 more element
A bioabsorbable medical device, comprising:
- a medical device having a structure, the medical device comprising a polymer melt blend of 78 weight percent to 82 weight percent of a first bioabsorbable polymer and 18 weight percent to 22 weight percent of a second bioabsorbable polymer,
- wherein the first bioabsorbable polymer comprises a lactide-rich polymer comprising 95 mol percent to 70 mol percent polymerized lactide and 5 mol percent to 30 mol percent polymerized glycolide, and the second bioabsorbable polymer comprises poly(p-dioxanone),
- wherein the polymer blend has a maximum weight percent of poly(p-dioxanone) of 22 weight percent and a minimum weight percent of poly(p-dioxanone) that depends upon the molar amount of polymerized lactide in the lactide-rich polymer and is calculated by the expression:
- Minimum Weight Percent Poly(p-dioxanone)=(215.6212/Mol Percent Polymerized Lactide)2.7027
- and wherein the polymer blend provides dimensional stability to a manufactured article.
2 more elements
Dependencies are inferred from the claim text.