Compositions and methods for the treatment of bone voids and open fractures
AssigneePolypid Ltd.
InventorNoam Emanuel
Life of this patent
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Abstract
The present invention relates to compositions, methods and medical devices for the treatment of bone voids and bone defects. The methods of the invention comprise the step of applying to a bone void or bone defect site a composition comprising a matrix which provides local prolonged release of at least one antibiotic agent at the bone void site.
Claims21
A medical device comprising coated and non-coated bone filler particles at a ratio of between about 1:3-10:1, wherein the coated bone filler particles comprise between about 80-90% (w/w) of bone filler and between about 10-20% (w/w) of a matrix composition which comprises:
- (a) 15-25% (w/w) PLGA;
- (b) 5-15% (w/w) of cholesterol;
- (c) 50-70% (w/w) of a mixture of DPPC and DSPC, wherein the ratio of DPPC to DSPC is between 5:1 and 2:1 and (d) 7-12% (w/w) of doxycycline or doxycycline hyclate.
A biocompatible matrix composition, comprising:
- (a) 15-25% (w/w) PLGA;
- (b) 5-15% (w/w) of cholesterol;
- (c) 50-70% (w/w) of a mixture of DPPC and DSPC, wherein the ratio of DPPC to DSPC is between 5:1 and 2:1 and (d) 7-12% (w/w) of doxycycline or doxycycline hyclate.
A method for treating an open bone fracture in a patient comprising implanting at the fracture site a medical device comprising coated and non-coated bone filler particles at a ratio of between about 1:3-10:1, wherein the coated bone filler particles comprise between about 80-90% (w/w) of bone filler and between about 10-20% (w/w) of a matrix composition which comprises:
- (a) 15-25% (w/w) PLGA;
- (b) 5-15% (w/w) cholesterol;
- (c) 50-70% (w/w) of a mixture of DPPC and DSPC, wherein the ratio of DPPC to DSPC is between 5:1 and 2:1;
- and (d) 7-12% (w/w) of doxycycline or doxycycline hyclate.
Dependencies are inferred from the claim text.