Biomaterial for wound healing
AssigneeKaohsiung Medical University
InventorsHui-Min Wang, Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Yi-Ting Chou, Ching-Ying Wu, Su-Shin Lee
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Abstract
The present invention provides a biomaterial comprising a scaffold consisting of collagen, hyaluronic acid, and gelatin, which are cross-linked via ethyl-3-[3-dimethylaminopropyl]carbodiimide (EDC) between any two of collagen, hyaluronic acid, and gelatin. The present invention further provides a method for preparing the biomaterial and a method for enhancing wound healing with the biomaterial.
Claims5
A biomaterial comprising a scaffold consisting of collagen, hyaluronic acid, and gelatin, wherein (1) collagen, hyaluronic acid, and gelatin are cross-linked via ethyl-3-[3-dimethylaminopropyl] carbodiimide (EDC);
- (2) the scaffold has the following structure:
- wherein X is gelatin-gelatin, gelatin-collagen, or gelatin-hyaluronic acid;
- Y is collagen-collagen, collagen-gelatin, or collagen-hyaluronic acid;
- Z is hyaluronic acid-gelatin, hyaluronic acid-collagen, or hyaluronic acid- hyaluronic acid;
- and n is an integer of 1 or more than 1;
- (3) the percentage of the collagen is 30% to 45%, the percentage of the hyaluronic acid is 0.1% to 5%, and the percentage of the gelatin is 50% to 70%, provided that total percentage of collagen, hyaluronic acid, and gelatin is 100%;
- and (4) the biomaterial has a swelling ratio more than 20 fold of dried scaffold.
Dependencies are inferred from the claim text.