Polysaccharide immunogens conjugated to E. coli carrier proteins
AssigneeGlaxosmithkline Biologicals SA
InventorsPaolo Costantino, Francesco Berti, Francesca Micoli, Anna Kabanova, Laura Serino, Maria Rosaria Romano, Marta Tontini
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Abstract
E. coli proteins have been identified that are useful as carrier proteins to improve a response to a polysaccharide immunogen conjugated to such protein. In particular, AcfD precursor protein (orf3526 polypeptide), Flu antigen 43 protein (orf1364 polypeptide), and Sel1 repeat-containing protein (upec-5211 polypeptide) have been shown to be effective. Additionally, these E. coli proteins can enhance the immune response to glucans, particularly fungal glucans.
Claims13
A polysaccharide conjugate comprising a polysaccharide conjugated to a carrier polypeptide selected from the group consisting of an E. coli AcfD precursor polypeptide (orf3526 polypeptide), an E. coli Flu antigen 43 polypeptide (orf1364 polypeptide), and an Escherichia Sel1 repeat-containing polypeptide (upec-5211 polypeptide).
Dependencies are inferred from the claim text.