US 9,173,952 B2Granted

Mitochondrial penetrating peptides as carriers for antimicrobials

AssigneeThe Governing Council of the University of Toronto

InventorsShana Kelley, Mark Pereira

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There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an antimicrobial, and their method of use.

Dependent claims

A composition comprising a peptide comprising the amino acid sequence of SEQ ID NO:

7, conjugated to 5-fluorouracil, gemcitabine, azathioprine, mecaptopurine, methotrexate,
raltitrexed, pemetrexed, 2-deoxyglucose, 3-bromopyruvate, oxamate or 6-aminonicotinamide.

Dependencies are inferred from the claim text.

A61K 47/64
The modifying agent being a protein, peptide or polyamino acid: drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying…
A61K 38/08
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: peptides having 5 to 11 amino acids
A61K 47/645
Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is…:…
A61P 31/00
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

From the US filing history. Foreign family members aren’t listed.

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