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US 9,173,951 B2Granted
Carbohydrate-based drug delivery polymers and conjugates thereof
AssigneeNektar Therapeutics
InventorsAntoni Kozlowski, Samuel P. McManus, Xiaoming Shen
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Abstract
Provided herein are water-soluble carbohydrate polymers which are monoderivatized at their reducing terminus, such that the carbohydrate polymers can be selectively conjugated at a single location. Also provided are methods of preparation and conjugation of the monoderivatized carbohydrate polymers.
Claims19
A conjugate comprising a monofunctional water-soluble carbohydrate-based reagent conjugated to a biologically active molecule (B), wherein the conjugate has a structure selected from
- where:
- POLY1 is a dextran polymer;
- and
- G2 is covalent bond comprising a residue or converted form of an aldehyde, a carboxylic acid or a carboxylic acid derivative, in each case following a reaction with a corresponding functional group on biologically active molecule (B).
1 more element
Dependencies are inferred from the claim text.