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US 9,173,947 B2Granted
Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom
AssigneeNektar Therapeutics
InventorsSamuel P. McManus, Antoni Kozlowski
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Abstract
The present invention provides, among other things, polymeric reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains and a plurality of hydroxyapatite-targeting moieties, and optionally the reagents include one or more degradable linkages that serve to divide the polymer chains into polymer segments having a molecular weight suitable for renal clearance.
Claims2
A heterobifunctional, substantially linear, hydroxyapatite-targeting polymer having the structure:
- Z—(X1)a-L1-(X2)b-[POLY1-(X3)c-L2-(X4)d]m-POLY2-(X5)e—Y
- wherein:
- each POLY1 and POLY2, which may be the same or different, is a water-soluble, non-peptidic polymer having a number average molecular weight of less than 8,000 Da;
- each X1, X2, X3, X4, and X5, which may be the same or different, is a spacer moiety;
- L1 is a linkage;
- each L2 is a hydrolytically or enzymatically cleavable linkage selected from the group consisting of carbamate and amide;
- Z is a hydroxyapatite-targeting moiety;
- Y is a functional group;
- each a, b, c, d, and e, which may be the same or different, is either zero or one;
- and
- m is an integer in the range of 1-10.
8 more elements
Dependencies are inferred from the claim text.