Back to results
US 9,173,944 B2Granted
Formulation suitable for stabilizing proteins, which is free of mammalian excipients
AssigneeMERZ PHARMA GmbH & CO. KGaA
InventorsHarold Victor Taylor, Gerd J. Mander, Markus Burger
Life of this patent
Estimating the term…
Abstract
A formulation free of protein which stabilizes pharmaceutical active proteins, peptides, or mixtures thereof in large scale production processes comprising a mixture of a hydrophilic polymer and a non-ionic detergent, and a mixture of a polyalcohol and a sugar. In some embodiments the polyalcohol is absent.
Claims15
A formulation free of proteins comprising,
- (a) a hydrophilic polymer;
- (b) a sugar;
- (c) a non-ionic detergent;
- and
- (d) a polyalcohol,
- wherein the weight ratio of polyalcohol to sugar is from 2:1 to 5:1 (wt-%), wherein the weight ratio between the hydrophilic polymer and the non-ionic detergent is from 18:1 to 22:1 (wt-%), and wherein the non-ionic detergent is present in said formulation in an amount between 0.2 and 0.01 mg/g.
3 more elements
A formulation free of proteins comprising,
- (a) a hydrophilic polymer;
- (b) a sugar;
- and
- (c) a non-ionic detergent,
- wherein the weight ratio between the hydrophilic polymer and the non-ionic detergent is from 2:1 to 30:1 (wt-%), and wherein the non-ionic detergent is present in the formulation in an amount between 0.2 and 0.01 mg/g, and wherein no polyalcohol is present.
2 more elements
Dependencies are inferred from the claim text.