Mixture of betamethasone and tranilast with a transdermal gel for scar treatment
AssigneeProfessional Compounding Centers of America (PCCA)
InventorDaniel Banov
Life of this patent
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Abstract
The present disclosure relates to a synergistic mixture of betamethasone valerate and tranilast combined with a transdermal gel using skin permeation enhancement for application in scars for reducing or preventing the abnormal scar formation, specially keloids and hypertrophic scars. The disclosed synergistic mixture may exhibit permeation enhancing properties. The transdermal gel may include a mixture of silicone, phosphatidylcholine, pracaxi oil, and seje oil; one or more oils having essential fatty acids, behenic acid, oleic acid; one or more skin lipids; a butter having linoleic acid and linolenic acid; and solvents as transdermal penetration enhancers.
Claims20
A formulation for inhibiting scar formation comprising:
- a) betamethasone valerate;
- b) tranilast;
- and
- c) a transdermal gel comprising about 10% w/w to about 95% w/w silicone;
- about 0.5% w/w to about 15% w/w pracaxi oil;
- about 0.5% w/w to about 15% w/w seje oil;
- and about 0.1% w/w to about 5% w/w phosphatidyl choline.
A formulation comprising
- a) about 0.1% w/w betamethasone valerate;
- b) about 1% w/w tranilast;
- and
- c) a transdermal gel comprising i) about 1% w/w to about 5% w/w pracaxi oil;
- ii) about 0.5% w/w to about 15% w/w seje oil;
- iii) about 0.5% w/w to about 2% w/w phosphatidyl choline;
- and iv) about 10% w/w to about 50% w/w silicone.
Dependencies are inferred from the claim text.