DNA vaccine for Alzheimer's disease
AssigneeYoh Matsumoto
InventorYoh Matsumoto
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Abstract
The invention provides a recombinant vector, which includes repeats of Amyloid β 1-42 (Aβ1-42) gene, an immunoglobulin Fc gene, a spacer sequence and interleukin-4 gene in this order, the repeats of the Aβ1-42 gene contain spacer sequences between the individual Aβ1-42 genes. The invention also provides a DNA vaccine for Alzheimer's disease, which includes the recombinant vector.
Claims17
A recombinant expression vector, which comprises repeats of Amyloid β 1-42 (Aβ1-42) coding sequence, an immunoglobulin Fc (IgFc) coding sequence, a second spacer coding sequence and an interleukin-4 (IL-4) coding sequence in this order, wherein the repeats of the Aβ1-42 coding sequence contain a first spacer coding sequence between the individual Aβ1-42 coding sequences, and the vector is capable of expressing a fusion protein combining repeats of the Aβ1-42 sequence, the IgFc sequence, the second spacer sequence and the IL-4 sequence, and wherein the IgFc coding sequence comprises SEQ ID NO:
- 32.
A recombinant vector, which comprises the nucleotide sequence shown in SEQ ID NO:
- 28 or 29.
Dependencies are inferred from the claim text.