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US 9,173,924 B2Granted
Stable glucagon peptide formulations
AssigneeZp Opco, Inc.
InventorsMahmoud Ameri, Peter E. Daddona, Yi Ao
Life of this patent
Estimating the term…
Abstract
There is provided glucagon formulations suitable for preparing coatings on microneedle patches for the transdermal delivery of glucagon. The coated patches may be used for the treatment of low blood sugar in diabetic patients. Also provided are glucagon loaded patches, methods for their preparation, and methods of their use.
Claims45
A liquid pharmaceutical formulation comprising
- a. 15-20% (w/w) of glucagon;
- b. 7.5-10% (w/w) of a stabilizing agent selected from either a cationic or neutral surfactant;
- c. 3.75-5% (w/w) of an amino acid;
- d. 3.75-5% (w/w) of an organic acid;
- and
- e. a pharmaceutically acceptable diluent;
- and
- wherein the formulation has a pH between 2 and 3.
5 more elements
A liquid pharmaceutical formulation comprising
- a. 15-20% (w/w) of glucagon;
- b. 7.5-10% (w/w) of a stabilizing agent comprising a surfactant that is a phospholipid;
- c. 3.75-5% (w/w) of an amino acid;
- d. 3.75-5% (w/w) of an organic acid;
- and
- e. a pharmaceutically acceptable diluent;
- and
- wherein the formulation has a pH between 2 and 3.
5 more elements
A solid pharmaceutical formulation comprising
- a. 40-50% (w/w) of glucagon or a glucagon-like peptide;
- b. 20-25% (w/w) of a stabilizing agent selected from either a cationic or neutral surfactant;
- c. 10-12.5% (w/w) of an amino acid;
- d. 10-12.5% (w/w) of an organic acid;
- and wherein the formulation has a pH between 2 and 3.
2 more elements
A solid pharmaceutical formulation comprising
- a. 40-50% (w/w) of glucagon or a glucagon-like peptide;
- b. 20-25% (w/w) of a stabilizing agent comprising a surfactant that is a phospholipid;
- c. 10-12.5% (w/w) of an amino acid;
- d. 10-12.5% (w/w) of an organic acid;
- and
- wherein the formulation has a pH between 2 and 3.
3 more elements
Dependencies are inferred from the claim text.