Modulating innate immune cell activity by lunasin and selected cytokines
AssigneeIndiana University Research and Technology Corporation
InventorHua-Chen Chang
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Abstract
This disclosure provides compositions and methods for enhancing innate immune system activities and responses by combining lunasin with at least one cytokine. The compositions synergistically enhance the effect of these selected cytokine(s), including but not limited to, activating Natural Killer (NK) cells, augmenting NK's cytotoxicity against viruses and tumors, regulating NK mediated anti-allergic inflammation, producing potent NK cells for cellular therapy using adoptive transfer. and facilitating dendritic cells antigen presentation.
Claims13
A combination therapy of lunasin and at least one cytokine selected from the group consisting of, interleukin 15 (IL-15) interleukin 18(IL-18), and interleukin 21 (IL21), wherein the combination therapy enhances the at least one cytokine's effect on an innate immune system.
A method of enhancing an innate immune system, the method comprising providing an individual with a pharmaceutically effective amount of a combination of lunasin and at least one cytokine selected from the group consisting of IL-15, IL-18, and IL-21.
A method of enhancing activity of natural killer (NK) cells, the method comprising providing an individual with a pharmaceutically effective amount of a combination of lunasin and at least one cytokine selected from the group consisting of IL-15, IL-18, and IL-21.
A method of increasing antibody dependent cell mediated cytotoxicity (ADCC) by natural killer (NK) cells, the method comprising providing an individual with a pharmaceutically effective amount of a combination of lunasin and at least one cytokine selected from the group consisting of IL-15, IL-18, and IL-21.
Dependencies are inferred from the claim text.