Methods for reducing oxidative stress in a cell with a sulfhydryl protected glutathione prodrug
AssigneesMax International, LLC, The United States of America as represented by the Department of Veteran Affairs
InventorsHerbert T. Nagasawa, Jonathan F. Cohen
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Abstract
The present invention relates to compositions and methods for reducing oxidative stress in a cell, increasing glutathione levels in a cell, increasing L-cysteine levels in a cell and reducing hepatocytotoxicity by contacting a cell with a sulfhydryl protected glutathione prodrug or a sulfhydryl protected cysteine prodrug.
Claims12
A method for reducing oxidative stress in a cell comprising administering L-CySSG to a subject, wherein L-CySSG is cleaved in the subject and releases cysteine and glutathione in the subject to reduce oxidative stress in the cell.
The method of 1, wherein L-CySSG is administered via aerosol, intravenous, intramuscular, subcutaneous, implantable pump, continuous infusion and/or oral administration.
Dependencies are inferred from the claim text.