Methods and compositions for tissue regeneration
AssigneeSmith & Nephew, Inc.
InventorsEric Rolland, Thomas Hunziker, Beatrice Chevallay, Christopher Rinsch
Life of this patent
Estimating the term…
Abstract
A kit is disclosed that includes a first component comprising alginate, wherein the first component is comprised in a first sterile vile, and a second component comprising cells comprising keratinocytes or fibroblasts, or mixtures thereof, that secrete one or more biologically active molecules selected from the group consisting of GM-CSF, VEGF, KGF, bFGF, TGFβ, angiopoietin, EGF, IL-Iβ, TGFα, and TNFα, wherein the cells are allogeneic and mitotically inactive, a buffered solution, and human serum albumin or a cryoprotectant, wherein the second component is comprised in a second vial.
Claims20
A composition comprising mitotically inactive autologous or allogeneic cells that are capable of secreting one or more biologically active molecules selected from GM-CSF, VEGF, KGF, aFGF, bFGF, TGFβ, angiopoietin, EGF, IL-1β, IL-6, IL-8, PDGF, HGF/SF, IGF-1, CSF-1, TGFα, and TNFα, wherein the composition is comprised in a buffered solution, a wound dressing, or an extracellular matrix or matrix material.
Dependencies are inferred from the claim text.