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AssigneeExcaliard Pharamaceuticals, Inc.
InventorsNicholas M. Dean, Lincoln Krochmal, Gregory Hardee, J. Gordon Foulkes, Niall O'Donnell, Leroy Young, Mark Jewell
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This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.
A method for treating a keloid, or preventing the formation, reformation, or growth of a keloid after an injury to the skin, in a subject in need thereof, which comprises administering to the subject by one or more injections at the site of the keloid or of the injury to the skin, a composition which comprises a modified oligonucleotide consisting of 12-30 linked nucleosides, at least a 12 nucleobase sequence portion of which is present within a region selected from nucleotides 553-611, 718-751, 1388-1423, 1457-1689, 2040-2069, 2120-2147, 2728-2797, 2267-2301, 1394-1423, 1469-1508, 1559-1605, 1659-1689, 2100-2129 and 1399-1423 of SEQ ID NO:
A method for treating a hypertrophic scar, or preventing the formation, reformation, or growth of a hypertrophic scar after an injury to the skin, in a subject in need thereof, which comprises administering to the subject by one or more injections at the site of the hypertrophic scar or of the injury to the skin, a composition which comprises a modified oligonucleotide consisting of 12-30 linked nucleosides, at least a 12 nucleobase sequence portion of which is present within a region selected from nucleotides 553-611, 718-751, 1388-1423, 1457-1689, 2040-2069, 2120-2147, 2728-2797, 2267-2301, 1394-1423, 1469-1508, 1559-1605, 1659-1689, 2100-2129 and 1399-1423 of SEQ ID NO:
A method for reducing formation, reformation, or growth of a scar or keloid at a site of an injury to the skin, or of treating a pre-existing scar or keloid, in a subject in need thereof, which comprises administering to the subject by one or more threading injections at the site of the injury or of the pre-existing scar or keloid, a composition which comprises a modified oligonucleotide, or a salt or ester thereof, targeted to a nucleic acid encoding a protein involved in fibrosis in an amount effective to inhibit expression of the protein and thereby reduce scar or keloid formation, reformation, or growth at the site of the injury or to treat the pre-existing scar or keloid.
A method for reducing formation, reformation, or growth of a fibrotic lesion at a site of an injury, or of treating a pre-existing fibrotic lesion, in a subject in need thereof, which comprises administering to the subject by one or more threading injections at the site of the injury or of the pre-existing fibrotic lesion, a composition which comprises a modified oligonucleotide, or a salt or ester thereof, targeted to a nucleic acid encoding a protein involved in fibrosis in an amount effective to inhibit expression of the protein and thereby reduce formation, reformation, or growth of the fibrotic lesion at the site of the injury or to treat the preexisting fibrotic lesion.
Dependencies are inferred from the claim text.