Acadesine derivatives, products and compositions including same, therapeutic uses thereof, and methods for synthesizing same

A method for treating cancer, the method comprising:

• administering to a patient in need thereof a compound of the general formula I in a suitable medium for administration to the patient;
• wherein general formula I is
• and wherein:
• R1 is chosen from:
• R2 is chosen from:
• a —CONH2, —CONHMe, —CONHEt, —CON(Me)2, —CON(Et)2 amide group,
• a —CO2H, CO2Me, CO2Et acid or ester group, a —CN, —C(NH2)NH, —C(NHMe)NH, —C(NHEt)NH cyano or amidine group,
• a phenyl group optionally substituted by a halogen chosen from Cl, Br, I and F,
• a thiophene group,
• a linear or branched carbon chain having 3 to 10 carbon atoms, or
• a methoxynaphthalene group;
• and
• R3 is chosen from:
• a halogen group,
• a furan or —CO-furan group,
• a thiophene or —CO-thiophene or —C≡C-thiophene group,
• a toluoyl group,
• an acetylene group,
• a —CO—(CH2)n—CH3 group, with n between 2 and 9,
• a phenyl or —C≡C-phenyl group, optionally substituted by a halogen,
• a —C≡C—CO2Me, —C≡C—CO2Et, —C≡C—CONH2 group,
• a —C≡C—(CH2)6CH3, group, or
• a —C≡C-2-methoxynaphthalene group;
• the racemates, enantiomers, diastereoisomers thereof and mixtures thereof, the tautomers thereof and the pharmaceutically acceptable salts thereof.