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US 9,173,883 B2Granted
Ring-substituted N-pyridinyl amides as kinase inhibitors
AssigneeNovartis AG
InventorsMatthew Burger, Joseph E. Drumm, III, Gisele Nishiguchi, Alice Rico, Robert Lowell Simmons, Benjamin Taft, Huw Tanner
Life of this patent
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Abstract
The present invention provides a compound of formula (A): as described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by PIM kinase using the compounds of Formula I, and pharmaceutical compositions comprising such compounds.
Claims20
A compound of Formula (A)
- wherein:
- groups attached to the ring containing Q that are depicted inside the ring are all syn to each other, and all groups attached to that ring that are depicted outside the ring are syn to one another;
- Q is C or N;
- Rq is H when Q is C, and Rd is absent when Q is N;
- R1 is selected from H, C1-4 alkyl, C3-6 cycloalkyl, C4-6 heterocyclyl, —(CR′2)1-3—OR′ and —OR′,
- where each R′ is independently H or C1-4 alkyl,
- and each alkyl, cycloalkyl and heterocyclyl is optionally substituted with up to two groups selected from halo, CN, NH2, hydroxy, oxo, C1-4 haloalkyl, C1-4 alkoxy, and C1-4 haloalkoxy;
- R1b, R1c, and R1d are each independently selected from H, halo, OR′, R′, —(CH2)1-2OR′, and CONR′2;
- one of R2a and R2b is H,
- and the other of R2a and R2b is selected from CN, azido, amino, —OR, —O(CH2)1-3OR, —NRC(O)R, —NRC(O)OR, —NHSO2R, —SO2R, —OSO2R, —SR, —S(O)R, —OP(O)R2, and 1-pyridonyl or 1-triazolyl optionally substituted with up to two groups selected from halo, C1-4 alkyl, hydroxy-substituted C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, C1-4 alkoxy, and C5-6 heteroaryl;
- where each R is independently C5-6 heteroaryl or C1-4 alkyl optionally substituted with up to three groups selected from cyano, halo, hydroxy, carboxy, C1-4 alkylsulfonyl, and C1-4 alkoxy;
- or R2a and R2b taken together may form a dialkyl ketal or 5-6 membered cyclic ketal, ═O or ═N—OR″, where R″ is H or C1-4 alkyl;
- ring A is selected from pyridinyl, pyrimidinyl, and pyrazinyl, each having N positioned as shown in Formula (I);
- and
- Ring A is optionally substituted with 1 or 2 groups selected from halo, CN, NH2, hydroxy, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, and C1-4 haloalkoxy;
- or a pharmaceutically acceptable salt thereof.
13 more elements
A compound selected from the group consisting of:
- N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-(2-methoxyacetamido)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-isobutyramido-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,5S,Z)-3-amino-4-(hydroxyimino)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(4-methyl-1H-1,2,3-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, ethyl (1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, isopropyl (1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-propionamidocyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,5S)-3-amino-5-methyl-4-oxocyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,5S,E)-3-amino-4-(methoxyimino)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,5S,Z)-3-amino-4-(methoxyimino)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-4-(4-(methoxymethyl)-1H-1,2,3-triazol-1-yl)-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-(2-hydroxyethylsulfonyl)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1S,3S,4S,5R)-3-amino-5-methyl-4-(methylsulfonamido)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-3-amino-5-methyl-4-(methylsulfonamido)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3,4-diamino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(methylsulfonamido)piperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-((2-methoxyethyl)sulfonyl)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-4-acetamido-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, methyl (1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, methyl (1R,2S,4S,6R)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, N-(4-((1S,3S,4R,5R)-4-acetamido-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-4-acetamido-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1S,3S,4R,5R)-3-amino-5-methyl-4-(methylsulfonamido)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(methylsulfonamido)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1S,3S,4R,5R)-3-amino-4-azido-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-azido-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-4-acetamido-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-3-amino-5-methyl-4-((R)-methylsulfinyl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-3-amino-5-methyl-4-((S)-methylsulfinyl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(methylthio)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-3-amino-5-methyl-4-(methylsulfonyl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-3-amino-5-methyl-4-(methylthio)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-((R)-methylsulfinyl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(methylsulfonyl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, (1R,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexyl dimethylphosphinate, (1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexyl dimethylphosphinate, (1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexyl methanesulfonate, (1R,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexyl methanesulfonate, N-(4-((6R,8R,10S)-6-amino-10-methyl-1,4-dioxaspiro[4.5]decan-8-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((6S,8S,10R)-6-amino-10-methyl-1,4-dioxaspiro[4.5]decan-8-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, 3-((1R,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexyloxy)propanoic acid, 3-((1S,2S,4S,6R)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexyloxy)propanoic acid, N-(4-((1S,3S,4R,5R)-3-amino-5-methyl-4-(1H-1,2,4-triazol-1-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,4-triazol-1-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)pyrimidine-4-carboxamide, methyl (1R,2S,4S,6R)-2-amino-4-(3-(6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexyl(methyl)carbamate, methyl (1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexyl(methyl)carbamate, N-(4-((3S,4S,5R)-3-amino-4-cyano-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,4-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((3S,4S,5R)-3-amino-4-cyano-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, methyl (3R,4S,5S)-3-amino-1-(3-(6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-yl(methyl)carbamate, methyl (1R,2S,4S,6R)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexyl(methyl)carbamate, methyl (1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexyl(methyl)carbamate, methyl (3R,4S,5S)-3-amino-1-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-yl(methyl)carbamate, N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(N-methylacetamido)piperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-4-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1S,3S,4R,5R)-3-amino-4-cyano-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-cyano-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, 5-amino-N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)pyrimidine-4-carboxamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamide, N-(4-((1S,3S,4R,5R)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1S,3S,4S,5R)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1S,3S,4R,5R)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, 5-amino-N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)pyrimidine-4-carboxamide, methyl ((3R,4S,5S)-3-amino-1-(3-(6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-yl)carbamate, methyl ((3R,4S,5S)-3-amino-1-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-yl)carbamate, N-(4-((1R,3R,4S,5S)-3-amino-4-(2-cyanoethoxy)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamide, N-(4-((1S,3S,4R,5R)-3-amino-4-(2-cyanoethoxy)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-(2-cyanoethoxy)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1S,3S,4R,5R)-3-amino-4-(2-cyanoethoxy)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-4-azido-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-ethoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1S,3S,4R,5R)-3-amino-4-ethoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamide, N-(4-((1S,3S,4R,5R)-3-amino-4-ethoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-ethoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(2-methoxyethoxy)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(4-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-isopropylphenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(4-fluorotetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(2-hydroxypropan-2-yl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(1-hydroxycyclobutyl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(4-(ethoxymethyl)-2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-isopropoxyphenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamide, N-(4-((1S,3S,4R,5R)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-methylsulfonyl)cyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)pyrimidine-4-carboxamide, methyl ((3R,4S,5S)-3-amino-1-(3-(6-(2,6-difluoro-4-(2-methoxyethoxy)phenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-yl)carbamate, methyl ((1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluoro-4-(2-methoxyethoxy)phenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexyl)carbamate, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(methylsulfonyl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(methylsulfonyl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(1-hydroxycyclobutyl)phenyl)-5-fluoropicolinamide, 3-amino-N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(methylsulfonyl)cyclohexyl)pyridin-3-yl)-6-(2-fluoro-5-(isopropylcarbamoyl)phenyl)picolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(methylsulfonyl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(4-fluorotetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamide, 3-amino-N-(4-((1R,3R,4S,5S)-3-amino-4-(2-cyanoethoxy)-5-methylcyclohexyl)pyridin-3-yl)-6-(2-fluoro-5-(isopropylcarbamoyl)phenyl)picolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(methylsulfonyl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methoxyphenyl)-5-fluoropicolinamide, N-(4-((1S,3S,4R,5R)-3-amino-5-methyl-4-(pyridin-2-yloxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, 3-amino-N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(methylsulfonyl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(methylsulfonyl)cyclohexyl)pyridin-3-yl)-6-(4-(ethoxymethyl)-2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(methylsulfonyl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(pyridin-2-yloxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(2-methoxyethoxy)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(4-(ethoxymethyl)-2,6-difluorophenyl)-5-fluoropicolinamide, 3-amino-N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2-fluoro-5-(isopropylcarbamoyl)phenyl)picolinamide, N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(4-fluorotetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamide, 3-amino-N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2-fluoro-5-(isopropylcarbamoyl)phenyl)picolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(4-fluorotetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(2-methoxyethoxyl)phenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-6-(2,6-difluoro-4-(2-methoxyethoxyl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(4-(ethoxymethyl)-2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(1-hydroxycyclobutyl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(1-hydroxycyclobutyl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-isopropoxyphenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-isopropoxyphenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methoxyphenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methoxyphenyl)-5-fluoropicolinamide, 3-amino-N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, 3-amino-N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-6-(2,6-difluoro-4-isopropoxyphenyl)-5-fluoropicolinamide, methyl (3R,4S,5S)-3-amino-1-(3-(6-(2,6-difluoro-4-isopropoxyphenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-ylcarbamate, methyl (1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluoro-4-isopropoxyphenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, N-(4-((1S,3S,4R,5R)-3-amino-5-methyl-4-(2-oxopyridin-1(2H)-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-6-(2,6-difluoro-4-(4-fluorotetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-oxopyridin-1(2H)-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-(2-cyanoethoxy)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(4-fluorotetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamide, N-(4-((1S,3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-Y1)cyclohexyl)pyridin-3-yl)-6-(4-(ethoxymethyl)-2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-6-(4-(ethoxymethyl)-2,6-difluorophenyl)-5-fluoropicolinamide, methyl (3R,4S,5S)-3-amino-1-(3-(6-(2,6-difluoro-4-(1-hydroxycyclobutyl)phenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-ylcarbamate, methyl (3R,4S,5S)-3-amino-1-(3-(6-(2,6-difluoro-4-tetrahydro-2H-pyran-4-yloxy)phenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-ylcarbamate, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-4Pyridin-3-yl)-6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-4Pyridin-3-yl)-6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamide, methyl (3R,4S,5S)-3-amino-1-(3-(6-(2,6-difluoro-4-(oxetan-3-yl)phenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-ylcarbamate, N-(4-((1R,3R,4S,5S)-3-amino-4-(2-cyanoethoxy)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(oxetan-3-yl)phenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-6-(2,6-difluoro-4-(oxetan-3-yl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-(2-cyanoethoxy)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methoxyphenyl)-5-fluoropicolinamide, 3-amino-N-(4-((1R,3R,4S,5S)-3-amino-4-(2-cyanoethoxy)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, methyl 1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluoro-4-(1-hydroxycyclobutyl)phenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, N-(4-((1R,3R,4S,5A)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(2-methoxyethoxyl)phenyl)-5-fluoropicolinamide, methyl (1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluoro-4-(tetrahydro-2H-pyran-4-yloxy)phenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(tetrahydro-2H-pyran-4-yloxy)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(1-hydroxycyclobutyl)phenyl)-5-fluoropicolinamide, methyl ((3R,4S,5S)-3-amino-1-(3-(6-(2,6-difluoro-4-methoxyphenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-yl)carbamate, methyl ((3R,4A,5S)-3-amino-1-(3-(3-amino-6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-yl)carbamate, methyl (1S,2R,4R,6S)-2-amino-4-(3-(3-amino-6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, 3-amino-N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, methyl (3R,4S,5S)-3-amino-1-(3-(6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-ylcarbamate, methyl (1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamide, methyl (1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinamide, methyl (1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluoro-4-(oxetan-3-yl)phenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, N-(4-((1R,3R,4S,5S)-3-amino-4-(2-cyanoethoxy)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-(2-cyanoethoxy)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(1-hydroxycyclobutyl)phenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-(4-cyano-1H-1,2,3-triazol-1-yl)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(4-(prop-1-en-2-yl)-1H-1,2,3-triazol-1-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-4-(4-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-1-yl)-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, 2-((1R,2S,4S,6R)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexyloxy)acetic acid, 2-((1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexyloxy)acetic acid, methyl (1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluoro-4-methoxyphenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-methoxyphenyl)-5-fluoropicolinamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-6-(2,6-difluoro-4-methoxyphenyl)-5-fluoropicolinamide, 3-amino-N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)cyclohexyl)pyridin-3-yl)-6-(2,6-difluoro-4-(4-fluorotetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamide, 3-amino-N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)cyclohexyl)pyridin-3-yl)-6-(2-fluoro-5-(isopropylcarbamoyl)phenyl)picolinamide, 3-amino-N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-6-(2-fluoro-5-(isopropylcarbamoyl)phenyl)picolinamide, methyl (3R,4S,5S)-3-amino-1-(3-(3-amino-6-(2-fluoro-5-(isopropylcarbamoyl)phenyl)picolinamido)pyridin-4-yl)-5-methylpiperidin-4-ylcarbamate, methyl (3R,4S,5S)-3-amino-1-(3-(6-(2,6-difluoro-4-(4-fluorotetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-ylcarbamate, methyl (1S,2R,4R,6S)-2-amino-4-(3-(3-amino-6-(2-fluoro-5-(isopropylcarbamoyl)phenyl)picolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, methyl 1S,2R,4R,6S)-2-amino-4-(3-(6-(2,6-difluoro-4-(4-fluorotetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, methyl (1S,2R,4R,6S)-2-amino-4-(3-(6-(4-(ethoxymethyl)-2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-6-methylcyclohexylcarbamate, methyl (3R,4S,5S)-3-amino-1-(3-(6-(4-(ethoxymethyl)-2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-4-ylcarbamate and the pharmaceutically acceptable salts thereof.
A compound selected from methyl (1R,2S,4S,6R)-2-amino-4-(3-(5-amino-2-(2,6-difluorophenyl)thiazole-4-carboxamido)pyridin-4-yl)-6-methylcyclohexyl(methyl)carbamate, methyl (1S,2R,4R,6S)-2-amino-4-(3-(5-amino-2-(2,6-difluorophenyl)thiazole-4-carboxamido)pyridin-4-yl)-6-methylcyclohexyl(methyl)carbamate, N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, 5-amino-N-(4-((3S,4S,5R)-3-amino-4-cyano-5-methylpiperidin-1-yl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, 5-amino-N-(4-((1S,3S,4R,5R)-3-amino-4-(2-cyanoethoxy)-5-methylcyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, 5-amino-N-(4-((1R,3R,4S,5S)-3-amino-4-(2-cyanoethoxy)-5-methylcyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, 5-amino-N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, 5-amino-N-(4-((1R,3R,4S,5S)-3-amino-4-ethoxy-5-methylcyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, methyl ((3R,4S,5S)-3-amino-1-(2-(5-amino-2-(2,6-difluorophenyl)thiazole-4-carboxamido)phenyl)-5-methylpiperidin-4-yl)carbamate, 5-amino-N-(4-((1R,3R,4S,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, 5-amino-N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(methylsulfonyl)cyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(methylsulfonyl)cyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, N-(4-((1R,3R,4R,5S)-3-amino-4-methoxy-5-methylcyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, 5-amino-N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(2-(methylsulfonyl)ethoxy)cyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, 5-amino-N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)cyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, 5-amino-N-(4-((3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide, N-(4-((1R,3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)cyclohexyl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide and a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.