US 9,173,876 B2 · Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide

Abstract

The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).

Claims1

Dependent claims

A method for treating a neuropathy, comprising administering to a patient in need thereof an effective amount of a compound (2S,3R)—N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide (Formula I) or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application

14/518,049Filed 20 Oct 2014 · continuation

Priority

26 Jan 2009

Published

US 2015/0105421 A116 Apr 2015

Granted

3 Nov 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification32 codes

A61K 31/444
Containing further heterocyclic ring systems: containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
A61P 1/02
Drugs for disorders of the alimentary tract or the digestive system: stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…

Family

Application61/147,260Us provisional application · filed 26 Jan 2009

PCT/US2010/021926Parent of this continuation · filed 25 Jan 2010

Application13/893,382Parent of this continuation · filed 14 May 2013

US 8,476,296 B2Parent of this continuation · filed 2 Jul 2013

US 2015/0105421 A1Pre-grant publication · published 16 Apr 2015

US 8,901,151 B2Parent of this continuation

Application12/740,970Parent of this continuation

US 2011/0257224 A1Published application

US 2014/0163065 A1Published application

US 9,173,876 B2This patent

From the US filing history. Foreign family members aren’t listed.

Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide

Life of this patent

Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide

Life of this patent

Abstract

Claims1