Mediators of hedgehog signaling pathways, compositions and uses related thereto

A compound of the formula (II):

• wherein, as valence and stability permit,
• R1 and R2, independently for each occurrence, are H, lower alkyl, substituted or unsubstituted —(CH2)naryl or substituted or unsubstituted —(CH2)nheteroaryl, wherein the optional substitutions are by halogen, cyano, unsubstituted alkyl, unsubstituted alkenyl, unsubstituted alkynyl, aryl, hydroxyl, unbranched alkyl-O—, silyloxy, amino, nitro, thiol, imino, amido, carboxyl, silyl, thioether, alkylsulfonyl, arylsulfonyl, sulfoxido, selenoether or ester, provided that, when R1 is substituted or unsubstituted —(CH2)naryl, n is 0;
• L adjacent to X is —(CH2)n′—where n′ is an integer of 1-10, -alkenyl-, -alkynyl-, —(CH2)nalkenyl-, —(CH2)nalkynyl-, —(CH2)nO(CH2)p—, —(CH2)nNR2(CH2)p—, —(CH2)nS(CH2)p—, —(CH2)nalkenyl(CH2)p—, —(CH2)nalkynyl(CH2)p—, —O(CH2)n—, —NR2(CH2)n—, or —S(CH2)n—;
• L, adjacent to R1 is absent,
• L adjacent to R2 is —(CH2)n—, -alkenyl-, -alkynyl-, —(CH2)nalkenyl-, —(CH2)nalkynyl-, —(CH2)nO(CH2)p—, —(CH2)nNR2(CH2)p—, —(CH2)nS(CH2)p—, —(CH2)nalkenyl(CH2)p—, —(CH2)nalkynyl(CH2)p—,—O(CH2)n—, —NR2(CH2)n—, or —S(CH2)n—;
• X—Y—Z together is —N(R12)—C(═O)—N(R8)—or —N(R 12)—C(═O)—, where R12 is lower alkyl;
• R8 is H, lower alkyl, substituted or unsubstituted —(CH2)naryl, or substituted or unsubstituted —(CH2)nheteroaryl;
• W is a substituted or unsubstituted benzene ring fused to the pyrimidone ring;
• p is, independently for each occurrence, an integer from 0 to 10;
• and
• n, independently for each occurrence, is an integer from 0 to 10;
• or a pharmaceutically acceptable salt thereof.