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US 9,173,868 B2Granted
Use of deoxyelephantopin (DET) and analogues thereof for reducing side effects of an anti-cancer agent
AssigneeAcademia Sinica
InventorsLie-Fen Shyur, Wen-Wan Chao, Ya-Wen Cheng
Life of this patent
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Abstract
Methods for preventing and/or reducing side effects of an anti-cancer agent in a subject in need thereof are disclosed. The method comprises administering to the subject, who is under an anti-cancer agent treatment, a composition comprising a therapeutically effective amount of isolated deoxyelephantopin and/or an analog thereof; and a pharmaceutically acceptable carrier.
Claims7
A method of reducing side effects of an anti-cancer agent in a subject in need thereof, comprising:
- administering to the subject, who is under an anti-cancer agent treatment, a composition comprising:
- (a) a therapeutically effective amount of isolated deoxyelephantopin, isodeoxyelephantopin, scabertopin, isoscabertopin, or any combination thereof;
- and
- (b) a pharmaceutically acceptable carrier,
- wherein the anti-cancer agent is at least one anti-melanoma agent selected from the group consisting of cisplatin, betulinic acid, 4-S-cysteaminyl catechol, 4-S-cysteaminyl phenol, everolimus, bortezomib, paclitaxel, carboplatin, dacarbazine, celecoxib, temozolomide, sorafenib, thalidomide, lenalidomide, oxaliplatin, docetaxel, valproic acid, vinblastine, imatinib mesylate, bosentan, doxorubicin, apomine, arsenic trioxide, carmustine and tamoxifen.
2 more elements
Dependencies are inferred from the claim text.