Compositions and products containing R-equol, and methods for their making
AssigneesChildren's Hospital Medical Center, Australian Health & Nutrition Association Limited
InventorsKenneth David Reginald Setchell, Sidney John Cole
Life of this patent
Estimating the term…
Abstract
A composition for use in making commercial food and skin products comprising R-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments. The compositions are useful in a method of delivering R-equol to a mammal to prevent or treat a disease or associated condition, including hormone-dependent diseases or conditions such as cardiovascular disease, lipid disorder, osteopenia, osteoporosis, liver disease, and acute ovarian estrogen deficiency. The R-equol enantiomer can be produced by chiral-phase column separation from a racemic mixture of equol.
Claims46
An oral pharmaceutical composition consisting essentially of the R enantiomer of equal (R-equol) and a pharmaceutically acceptable adjuvant, carrier, diluent, filler and/or excipient, wherein the R-equol is present in an amount sufficient to achieve a health benefit in a mammal.
An oral pharmaceutical composition comprising enantiomerically pure R-equol as an active agent and a pharmaceutically acceptable adjuvant, carrier, diluent, filler and/or excipient, wherein the R-equol is present in an amount sufficient to achieve a health benefit in a mammal.
An orally consumable composition comprising enantiomerically pure R-equol as an active agent and an adjuvant, carrier, diluent, filler, excipient and/or food component, wherein the R-equol is present in an amount sufficient to achieve a health benefit in a mammal.
An orally consumable composition consisting essentially of equol and an adjuvant, carrier, diluent, filler, excipient and/or food component, wherein the equol is present as a non-racemic mixture having an excess of the R-enantiomer of equol (R-equol) and wherein the R-equol is present in an amount sufficient to achieve a health benefit in a mammal.
A method of ameliorating benign prostatic hyperplasia in a subject, comprising administering a non-racemic mixture of equol, wherein the equol consists of more than 50 percent R-equol to the subject.
Dependencies are inferred from the claim text.