Glycyrrhetinic acid-mediated nanoparticles of hepatic targeted drug delivery system, process for preparing the same and use thereof
AssigneesTian Si Polymer Materials Technology Development Co., Nankai University
InventorsZhi Yuan, Wei Huang, Qin Tian, Chuangnian Zhang, Liang Han, Tong Liu, Yue Zhang, Yue Chen
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Abstract
Disclosed are a hepatic targeted drug delivery system and a process for preparing the same. Also disclosed is a method for treating liver cancer.
Claims18
A hepatic targeted nanoparticle comprising an anticancer agent and a carrier comprising a polysaccharide and polyethylene glycol (PEG)-glycyrrhetinic acid (GA)
- wherein the nanoparticle is prepared by a process comprising (a) modifying diamino-PEG with glycyrrhetinic acid (GA) to obtain a GA-modified PEG (PEG-GA);
- (b) physically mixing the PEG-GA with the polysaccharide to obtain a polysaccharide/PEG-GA;
- and
- (c) loading an anticancer agent to the polysaccharide/PEG-GA with an ion cross-linker to obtain the nanoparticle.
A process for preparing a hepatic-targeted nanoparticle comprising an anticancer agent and a carrier comprising polyethylene glycol (PEG)-glycyrrhetinic acid (GA) and a polysaccharide the process comprising
- (a) modifying diamino-PEG with glycyrrhetinic acid (GA) to obtain a GA-modified PEG (PEG-GA);
- (b) physically mixing the PEG-GA with the polysaccharide to obtain a polysaccharide/PEG-GA;
- and
- (c) loading an anticancer agent to the polysaccharide/PEG-GA with an ion cross-linker to obtain the nanoparticle.
Dependencies are inferred from the claim text.