Stable pharmaceutical composition comprising a hydrosoluble vinflunine salt
AssigneePierre Fabre Medicament
InventorsBruno Paillard, Jean-Louis Avan, Joël Bougaret
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Abstract
Stable pharmaceutical composition consisting of a hydrosoluble vinflunine salt and at least one diluent and one lubricant, said composition being in the form of a solid intended for oral administration. The hydrosoluble vinflunine salt is preferably Vinflunine ditartrate. The pharmaceutical composition is advantageously in the form of a capsule or tablet. The invention also concerns a method of treating cancer pathology comprising the oral administration of the pharmaceutical composition of the invention.
Claims22
A stable pharmaceutical composition comprising a hydrosoluble vinflunine ditartrate salt and at least one diluent, at least one binder, at least one disintegrant and at least one lubricant, said composition being presented in solid form intended for oral administration wherein
- the stable pharmaceutical composition contains 35 to 55% by weight of the hydrosoluble vinflunine ditartrate salt,
- the proportion of diluent is between 20 and 60% of the total weight of the composition,
- the proportion of the lubricant is between 1 and 5% of the total weight of the composition, and
- the proportion of the disintegrant is between 2 and 8% of the total weight of the composition, and
- wherein the composition is stable for over a period of 3 months allowing a shelf-life of about 24 months at 5° C.
Dependencies are inferred from the claim text.